Cannabinoids Explained: CBC

CBC has been shown to promote bone growth, inhibit the spreading of cancer cells, aid in pain relief and reduce inflammation. Written by Anna Barberena.

What is CBC?

While cannabichromene is considered one of the most common cannabinoids, it is rarely ever found in high quantities in mature cannabis. It does not produce much activity at the CB1 or CB2 sites but it still offers some potent therapeutic effects (2). Since it does not bind actively to the CB1 receptor, there is no direct intoxication associated with this cannabinoid. CBC has been shown to promote bone growth, inhibit the spreading of cancer cells, aid in pain relief and reduce inflammation (2). It is also a potent anti-microbial, antibacterial and antifungal agent (2). A preliminary study suggests that CBC produces significantly higher rates of cell death in gastrointestinal cancers (6).

What is CBC?

According to Dr. Dustin Sulak, the Therapeutic Effects of CBC are:

  • Anti-microbial
  • Pain Reduction (analgesia)
  • Bone stimulant
  • Antibacterial
  • Antifungal
  • Anti-inflammatory

Entourage Effects

  • CBC, taken with THC, increases the anti-inflammatory effects of both cannabinoids (4)
  • When CBC is combined with THC and CBD the antidepressant properties of all three cannabinoids are increased (5)
  • CBD and CBC taken together have been shown to decrease pain perception by interacting with pathways that influence the control of pain (3)

Conditions CBC may be beneficial for

  • Irritable bowel syndrome
  • Crohn’s disease
  • Neuropathy
  • Chronic postoperative pain
  • Acne
  • Cancer

Potential Adverse Side Effects

Citations: 1. Mack, Elizabeth. “Cannabinoids” Holistic Caring Network, 2021, 2. Sulak, Dustin. “The Pharmacology of Cannabis.” Medical Cannabis Core Curriculum, 3. Maione, Sabatino, et al. “Non-Psychoactive Cannabinoids Modulate the Descending Pathway of Antinociception in Anaesthetized Rats through Several Mechanisms of Action.” British Journal of Pharmacology, vol. 162, no. 3, 2011, pp. 584–596., Accessed 5 Nov. 2021. 4. DeLong, Gerald T et al. “Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Δ(9)-tetrahydrocannabinol.” Drug and alcohol dependence vol. 112,1-2 (2010): 126-33. doi:10.1016/j.drugalcdep.2010.05.019 5. El-Alfy AT, Ivey K, Robinson K, Ahmed S, Radwan M, Slade D, Khan I, ElSohly M, Ross S. Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. Pharmacol Biochem Behav. 2010 Jun;95(4):434-42. doi: 10.1016/j.pbb.2010.03.004. Epub 2010 Mar 21. PMID: 20332000; PMCID: PMC2866040. 6. Ligresti, Alessia, et al. “Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma.” Journal of Pharmacology and Experimental Therapeutics, vol. 318, no. 3, 2006, pp. 1375–1387., Accessed 5 Nov. 2021.

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